Increased platelet release of superoxide anion in hypertensives
نویسندگان
چکیده
منابع مشابه
Superoxide anion release induced by platelet-activating factor is increased in human alveolar macrophages from smokers.
This study was designed to investigate the effects of the platelet-activating factor (PAF) on the superoxide anion production (O2.) of human alveolar macrophages (AM) from nonsmoking (n = 18) and smoking (n = 30) subjects. Freshly isolated cells were stimulated with (PAF) or with a phorbol ester (phorbol 12-myristate 13 acetate (PMA)). Stimulation with PAF led to a dose-dependent increase of O2...
متن کاملNAD(P)H oxidase-dependent platelet superoxide anion release increases platelet recruitment.
Platelets, although not phagocytotic, have been suggested to release O. Since O-producing reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) oxidases can be specifically activated by certain agonists and are found in several nonphagocytotic tissues, we investigated whether such an enzyme is the source of platelet-derived O. We further studied which agonists cause platelet O release...
متن کاملNeutrophil signal transduction in Met-enkephalin modulated superoxide anion release.
The present study explored the involvement of signal transduction system(s) in Met-enkephalin (MENK) modulated superoxide anion (O2-) release from human neutrophils. This opioid pentapeptide stimulated the O2- release in all samples if present at 10(-8) M concentration while in lower concentrations the stimulatory concentration was donor-dependent. The most abundant product of MENK degradation,...
متن کاملNeutrophil Superoxide Anion Production
Superoxide and other oxygen radicals produced by activated polymorphonuclear leukocytes (PMN) may be important causes of tissue damage in a number ofinflammatory conditions. Therefore, a drug which suppresses PMN responses in vivo is potentially important. In vitro, pentoxifylline (PTOX) inhibits superoxide anion production when PMN are stimulated with an activated complement component (C5a Des...
متن کاملRole of Superoxide Anion Radicals
The discovery that macrophages metabolize ethanol to acetate in vitro may be of importance in understanding the pathogenesis of ethanol-induced tissue damage (1) . When expressed per unit wet weight, the rate of metabolism ofethanol by these cells is comparable to that by hepatocytes (2) . Studies of human and murine macrophages derived from various tissues have revealed that ethanol oxidation ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2000
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(00)00954-7